The project «A Ca2+-binding protein, recoverin as a paraneoplastic antigen and a potential marker of small cell lung carcinoma»

Project Leader: Pavel P. PHILIPPOV, Dr. of Science (Biolology), Professor of 
Biochemistry, Head of the Department of Enzymology, A.N.Belozersky Institute of 
Physico-Chemical Biology, Moscow State University.
Address: A.N.Belozersky Institute of Physico-Chemical Biology, Moscow State 
University, 119899 Moscow, Russia.
Tel.: 7(095) 939-50-17,  fax: 939-09-78. 
E-mail: < ppph@genebee.msu.su >

Main research directions of the Department:
1. Calcium-binding protein, recoverin and other paraneoplastic antigens as potential 
markers of cancer.
2. Molecular mechanisms of visual transduction.

Main scientific results:
1. Prediction of the existence of the transducin GTPase activator in rod outer 
segments [Arshavsky V.Yu., Antoch M.P., Lukjanov K.A., Philippov P.P. (1989) 
FEBS Lett. 250, 353-356].
2. Discovery of the novel visual Ca2+-binding protein, recoverin and its ability to bind 
to membranes in a Ca2+-dependent manner [Dizhoor A.M., Nekrasova E.R., 
Philippov P.P. (1991) Biochemistry (Moscow) 56, 225-229; Dizhoor et al. (1991) 
Science 251, 915-918; Dizhoor et al. (1993) Science 259, 829-832].
3. Identification of rhodopsin kinase as the recoverin intracellular target
     [Gorodovikova E.N., Philippov P.P (1993) FEBS Lett. 335, 277-279; 
     Gorodovikova E.N. et al. (1994) FEBS Lett. 349, 187-190; Gorodovikova E.N.,  
Senin I.I., Philippov P.P (1994) FEBS Lett. 353, 171-172].

Honours, Distinctions and Grants:
1981        Government Award for the Applied Work in Biotechnology (Russia).
1990-91     Grant (fellowship) of CNRS (France).
1992-95	    Grant of the International Human Frontier Science Program Organization.                                   
1994-95     Grant of the International Science Foundation.
1994-97	    Grant of the Royal Society (UK).
1997        Yu.A.Ovchinnikov Award of the Russian Academy of Sciences.
1997,98     Professorship of the International Soros Scince Education Program.
1999        Annual Bakh’s Lecture, the Russian Academy of Sciences.
1998-01	    Grant of the Wellcome Trust (UK).
1994-96,    Fellowship of the President of Russia for Outstanding Scientists.
1997-99,
2000-02
1994-96,    Grant of the Russian Foundation for Basic Research.
1997-99,
2000-02
2000-02     Grant of the Ludwig Institute for Cancer Research.